PERK Signaling Maintains Hematopoietic Stem Cell Pool Integrity under Endoplasmic Reticulum Stress by Promoting Proliferation.

The article discusses the role of PERK signaling in maintaining the integrity of the hematopoietic stem cell (HSC) pool under endoplasmic reticulum stress by promoting proliferation. While PERK is not essential for normal hematopoiesis and HSC self-renewal under steady-state conditions, it becomes activated in response to ER stress induced by the inactivation of ER-associated degradation (ERAD). This activation of PERK leads to abnormal proliferation of HSCs, removing stressed HSCs and maintaining HSC pool integrity. The study highlights a PERK-centered strategy used by HSCs to preserve their pool integrity independently of apoptosis. [Extracted from the article]

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