An unusual reaction of benzalaminoacetals in trifluoroacetic acid: facile synthesis of 2-benzylpyrazines.

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  • Author(s): Augustine JK;Augustine JK; Naik YA; Mandal AB; Kundapur U
  • Source:
    The Journal of organic chemistry [J Org Chem] 2008 Feb 01; Vol. 73 (3), pp. 1176-9. Date of Electronic Publication: 2008 Jan 10.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3263 (Print) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE
    • Publication Information:
      Publication: Columbus Oh : American Chemical Society
      Original Publication: Easton, Pa. [etc.]
    • Subject Terms:
      Acetals/*chemistry ; Benzene/*chemistry ; Pyrazines/*chemical synthesis ; Trifluoroacetic Acid/*chemistry; Molecular Structure ; Pyrazines/chemistry
    • Abstract:
      Benzalaminoacetals (1), upon refluxing with trifluoroacetic acid, lead to 2-benzylpyrazines, rather than the expected isoquinolines. This unusual reaction represents another useful way to prepare a variety of 2-benzylpyrazines from the corresponding benzaldehydes.
    • Accession Number:
      0 (Acetals)
      0 (Pyrazines)
      E5R8Z4G708 (Trifluoroacetic Acid)
      J64922108F (Benzene)
    • Publication Date:
      Date Created: 20080111 Date Completed: 20080403 Latest Revision: 20131121
    • Publication Date:
      20221213
    • Accession Number:
      10.1021/jo702448a
    • Accession Number:
      18184011