Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors.

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  • Author(s): Yamanaka S;Yamanaka S
  • Source:
    Cell proliferation [Cell Prolif] 2008 Feb; Vol. 41 Suppl 1, pp. 51-6.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9105195 Publication Model: Print Cited Medium: Internet ISSN: 1365-2184 (Electronic) Linking ISSN: 09607722 NLM ISO Abbreviation: Cell Prolif Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Oxford, England] : Published for the Cell Kinetics Society, the European Study Group for Cell Proliferation, and the International Cell Cycle Society by Blackwell Scientific Publications, 1991-
    • Subject Terms:
      Cell Differentiation/*physiology ; Fibroblasts/*cytology ; Pluripotent Stem Cells/*cytology ; Transcription Factors/*physiology; Animals ; Cells, Cultured ; Fibroblasts/physiology ; Kruppel-Like Factor 4 ; Mice ; Pluripotent Stem Cells/physiology
    • Abstract:
      Pluripotent stem cells, such as embryonic stem cells (ESCs), proliferate rapidly while maintaining pluripotency, namely, the ability to differentiate into various types of cells. Embryonic stem cells are promising donor sources for cell transplantation therapies. However, human ESCs are also associated with ethical issues regarding the use of human embryos and rejection reactions after allogenic transplantation. It may be possible to overcome these issues by generating pluripotent stem cells directly from a patient's somatic cells. That somatic cell nuclei acquire an embryonic stem-like status by fusion with ESCs suggests the existence of 'pluripotency-inducing' factors. Previous studies have recently shown that retrovirus-mediated transfection with four transcription factors (Oct-3/4, Sox2, KLF4 and c-Myc), which are highly expressed in ESCs, into mouse fibroblasts has resulted in generation of induced pluripotent stem (iPS) cells. iPS cells are similar to ESCs in morphology, proliferation, and pluripotency, judged by teratoma formation and chimaera contribution. If iPS cells can be derived from human somatic cells, then such cells may thus lead to important drug discoveries and advances in regenerative medicine.
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    • Accession Number:
      0 (KLF4 protein, human)
      0 (Klf4 protein, mouse)
      0 (Kruppel-Like Factor 4)
      0 (Transcription Factors)
    • Publication Date:
      Date Created: 20080110 Date Completed: 20080408 Latest Revision: 20211203
    • Publication Date:
      20231215
    • Accession Number:
      PMC6496227
    • Accession Number:
      10.1111/j.1365-2184.2008.00493.x
    • Accession Number:
      18181945