Neutrophils from patients with acquired neutropenia exhibit alterations in serine protease immunostaining and activity.

The article published in the British Journal of Haematology explores alterations in neutrophils from patients with acquired neutropenia, focusing on neutrophil serine proteases (NSPs) such as neutrophil elastase (NE) and cathepsin G (CG). The study compares these enzymes in patients with chronic idiopathic neutropenia (CIN) to healthy donors, revealing differences in immunostaining and activity levels. The findings suggest potential indicators or contributing factors to the development of CIN, highlighting the need for further mechanistic studies in different forms of neutropenia. [Extracted from the article]

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