Isoflavones obtained from red clover improve both dyslipidemia and menopausal symptoms in menopausal women: a prospective randomized placebo-controlled trial.

Objective: This study aimed to investigate the effects of red clover isoflavones on menopausal symptoms and the lipid profile in menopausal females. Methods: This study included postmenopausal women with dyslipidemia. The red clover group (n = 39) received 40 mg isoflavone red clover capsule twice daily for 6 months, while placebo (n = 36) was 40 mg starch capsule twice daily. Data were collected at baseline, 3 months and 6 months. The Menopause Rating Scale (MRS) was applied to calculate subdimension and total scores. Results: The two groups were similar in terms of age, MRS and lipid profile at baseline. In the red clover group, MRS scores decreased significantly at both 3 and 6 months. Similarly, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglyceride levels decreased at both 3 months and 6 months. High-density lipoprotein cholesterol increased significantly from baseline to 3 months and 6 months. Except for LDL-C and MRS urogenital score at 3 months, the improvements were significantly in favor of red clover isoflavone treatment. Conclusions: Red clover treatment for 3–6 months demonstrated significant improvements in lipid profiles and menopausal symptoms. While promising, further research is crucial to ascertain long-term safety and recommend the use of red clover isoflavones during menopause. [ABSTRACT FROM AUTHOR]

本研究旨在探讨红三叶草异黄酮对绝经女性绝经症状和血脂水平的影响。 本研究纳入患有血脂异常的绝经女性。红三叶草组(n = 39)每日服用40 mg红三叶草异黄酮胶囊两次, 持续6个月；安慰剂组(n = 36)每日服用40 mg淀粉胶囊两次。数据分别在基线、第3个月和第6个月时收集。应用绝经评分量表(MRS)计算各维度得分和总分。 两组在基线时的年龄、MRS评分和血脂水平相似。在红三叶草组, 第3个月和第6个月的MRS评分均显著下降。同样, 总胆固醇、低密度脂蛋白胆固醇(LDL-C)和甘油三酯水平在第3个月和第6个月均有所下降。而高密度脂蛋白胆固醇(HDL-C)从基线到第3个月和第6个月显著升高。除第3个月的LDL-C和MRS泌尿生殖维度评分外, 其余指标的显著改善均支持红三叶草异黄酮的疗效。 为期3到6个月的红三叶草治疗显著改善了绝经女性的血脂水平和绝经症状。尽管这一结果具有良好的前景, 但仍需进一步研究以明确其长期安全性, 并评估红三叶草异黄酮在绝经期间的使用建议。 [ABSTRACT FROM AUTHOR]

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