Researchers Submit Patent Application, "Mammalian Artificial Chromosome Vector Having Human Immunoglobulin Heavy Chain Locus Comprising Modified D-Region, And Cell Or Non-Human Animal Retaining The Vector", for Approval (USPTO 20240392313).

Researchers have submitted a patent application for a mammalian artificial chromosome vector that aims to expand the human antibody repertoire in non-human animals. The invention focuses on modifying the D-region of the human immunoglobulin heavy chain locus to enhance antibody production against infectious diseases like HIV, COVID-19, and influenza. By utilizing a combination of human and non-human genomic sequences, the patent seeks to develop a platform for generating antibodies with unique properties. This innovative approach could potentially lead to the creation of more effective therapeutic agents and vaccines. [Extracted from the article]

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