Chungbuk National University Researchers Focus on Liver Cancer (Integration of epigenomic and transcriptomic profiling uncovers EZH2 target genes linked to cysteine metabolism in hepatocellular carcinoma).

Researchers at Chungbuk National University have conducted a study focusing on liver cancer, specifically exploring the role of the protein EZH2 in hepatocellular carcinoma (HCC). Through epigenomic and transcriptomic analyses, they found that EZH2 overexpression is associated with poor patient survival in HCC. Inhibition of EZH2 led to changes in gene expression related to cysteine metabolism and lipid homeostasis, suggesting a potential therapeutic target for HCC treatment. The study highlights a novel epigenetic mechanism controlling lipid peroxidation and ferroptosis susceptibility in liver cancer, providing insights for future EZH2-targeted therapies. [Extracted from the article]

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