An mTOR-Tfeb-Fabp7a signaling axis can be harnessed to ameliorate bag3 cardiomyopathy in adult zebrafish.

The article discusses the potential therapeutic benefits of targeting the mTOR-Tfeb-Fabp7a signaling axis to ameliorate bag3 cardiomyopathy in adult zebrafish. By overexpressing the transcription factor EB (tfeb) gene and inhibiting the fatty acid binding protein a (fabp7a) gene, researchers were able to repair defective proteostasis, attenuate cardiac senescence, and rescue cardiac dysfunction in the zebrafish model. These findings suggest that targeting this signaling axis could have cardioprotective effects in individuals with bag3 cardiomyopathy. [Extracted from the article]

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