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Characterization of the membrane vesicle fraction from Acetobacter sp. WSS15.
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- Author(s): Kurata, Atsushi1 (AUTHOR) ; Aimatsu, Kota1 (AUTHOR); Kimura, Yuki1 (AUTHOR); Hashiguchi, Hinako1 (AUTHOR); Maeda, Asami1 (AUTHOR); Imai, Tomoya2 (AUTHOR); Yamasaki-Yashiki, Shino3 (AUTHOR); Hamada, Kensaku4 (AUTHOR); Fujimoto, Yuki4 (AUTHOR); Fujii, Akira4 (AUTHOR); Uegaki, Koichi1,5 (AUTHOR)
- Source:
Journal of Bioscience & Bioengineering. Dec2024, Vol. 138 Issue 6, p495-500. 6p.
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- Abstract:
A bacterium that produces membrane vesicles (MVs), strain WSS15, was isolated from a traditional vinegar in Japan called Kurozu. A phylogenetic analysis of 16S rRNA gene sequences indicated that this bacterium belongs to the genus Acetobacter. MVs and peptidoglycan-associated lipoprotein (Pal) were detected in the MV fraction of strain WSS15. In the presence of the WSS15 MV fraction, murine macrophages produced the pro-inflammatory cytokine interleukin-6 (IL-6) via the recognition by superficial Toll-like receptor 2 (TLR2). WSS15 MVs adhered to the cell surface of macrophages. The macrophages secreted IL-6 through the TLR2 recognition of an acylated N-terminal peptide of Pal. We elucidated the mode of action of WSS15 MVs on immune cells and identified the Pal peptide from strain WSS15 as an agonist of TLR2. [ABSTRACT FROM AUTHOR]
- Abstract:
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