Advances in the synthesis of (3R,3aS,6aR)-hexahydrofuro-[2,3-b]furan-3-ol, a key ligand of the HIV protease inhibitors.

(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol (bis-THF alcohol) is a key intermediate for the synthesis of HIV protease inhibitors with lower toxicity and better drug resistance. Due to its unique structure with three chiral centers and the high cost of this double-ring compound, chemists have paid much attention to the development of new synthetic routes. Based on the sources of the chiral carbon in bis-THF alcohol, this work systematically summarizes the existing synthetic processes using enzyme-catalyzed resolution, asymmetric metal catalysis, and chiral-substrate-induced reactions. [ABSTRACT FROM AUTHOR]

Copyright of Chemistry of Heterocyclic Compounds is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)