Hochauflösende Strukturanalysen von eukaryotischen Zell-Maschinen. (German)

Chaetomium thermophilum is an eukaryotic thermophilic fungus that holds great potential for broad biochemical and biotechnological applications. We have developed a tool box for its genetic manipulation rendering this organism amenable as resource for structural biology. Here, we elucidate these approaches as a foundation for affinity purification of thermostable macromolecular complexes, like nucleoporin complexes and pre-ribosomal particles. [ABSTRACT FROM AUTHOR]

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