Editorial: Hepatocyte nuclear factor 4 alpha - new insights into an old receptor.

This article provides an overview of the hepatocyte nuclear factor 4 alpha (HNF4a) and its role as a regulator of liver-specific transcription. It discusses the evolutionary origins of HNF4a, its association with human diseases, and its expression in other tissues. The article also highlights the importance of HNF4a in metabolism and its potential role in diseases like diabetes. Additionally, the article examines a specific genetic polymorphism (HNF4A rs1800961) and its association with the development of gallstones in a Taiwanese population. The study found that individuals with this polymorphism had a higher risk of developing gallstones. Further research is needed to understand the underlying mechanisms. [Extracted from the article]

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