Recent Studies from Tongji University Add New Data to CCN Intercellular Signaling Proteins (Vascular endothelial growth factor/connective tissue growth factor and proteomic analysis of aqueous humor after intravitreal conbercept for...).

A recent study from Tongji University investigated the role of connective tissue growth factor (CTGF) and vascular endothelial growth factor (VEGF) in the protein profile of the aqueous humor in patients with proliferative diabetic retinopathy (PDR) following intravitreal injection of conbercept. The study found that intravitreal conbercept effectively reduced VEGF levels while increasing CTGF levels, thereby modifying the CTGF/VEGF ratio. Proteomic analysis revealed that these changes were associated with critical biological pathways and protein interactions involved in immune response, stress response, and cellular metabolism. This research provides valuable insights into the effects of intravitreal conbercept on the protein profile of patients with PDR. [Extracted from the article]

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