Structural basis for the access and binding of resolvin D1 (RvD1) to formyl peptide receptor 2 (FPR2/ALX), a class A GPCR.

This article discusses the role of specialized pro-resolving lipid mediators (SPMs), specifically resolvins, in the resolution of inflammation. The study focuses on resolvin D1 (RvD1) and its binding to the class A G protein-coupled receptor FPR2/ALXR. The researchers used simulations to examine the structural basis for the access and binding of RvD1 to its target receptor. The findings provide insights into the access path and key interactions involved in the binding process, which could potentially aid in the development of small molecule therapeutics for inflammatory disorders. [Extracted from the article]

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