Altered oral microbiota of drug-resistant organism carriers exhibit impaired gram-negative pathogen inhibition.

A preprint abstract from biorxiv.org discusses the understudied role of the oral microbiome in harboring drug-resistant pathogens. The study examined the oral microbiomes of individuals colonized by multidrug-resistant organisms (MDROs) and compared them to non-colonized controls. The findings revealed significant differences in microbial communities, with depletion of Streptococcus spp. among MDRO carriers. The study also found higher abundance of antimicrobial resistance genes in MDRO carriers and demonstrated that oral bacteria from non-carriers exhibited greater inhibition of gram-negative pathogens. The research suggests that the oral microbiota may play a role in shaping the microbial community and could potentially serve as a source for antimicrobial small-molecules. [Extracted from the article]

Copyright of Drug Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)