Loyola University Chicago Researchers Discuss Research in Enzymes and Coenzymes (Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses).

A recent report from Loyola University Chicago discusses research on enzymes and coenzymes, specifically focusing on age-associated inflammasome activation and its impact on inflammatory responses. The study found that aging is associated with chronic, low-grade inflammation known as "inflammaging," which is driven by various inflammatory pathways, including the inflammasome. The researchers used transgenic mice to examine inflammasome activation in different organs and tissues, revealing that the degree of activation varies between tissues and is not always correlated with transcriptional changes. Additionally, the study introduced new methodologies for measuring age-associated inflammasome activation in vivo and ex vivo. [Extracted from the article]

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