An Endometrial Stem Cell Pioneer: Two decades ago, Caroline Gargett identified adult stem cells in the endometrium. Now, she explores their functions to improve women's health.

Caroline Gargett, a biologist at the Hudson Institute of Medical Research, has been studying adult stem cells in the endometrium for the past twenty years. Her research focuses on understanding the functions of these stem cells and their role in gynecological conditions like endometriosis. The discovery of these cells has provided valuable insights into endometrial regeneration and repair, and their potential use in treating diseases that affect women's health. Gargett is also investigating the use of endometrial stem cells in developing new treatments for pelvic organ prolapse. Researchers have developed a mesh coated with gelatin and seeded with human endometrial stem cells, which has shown promising results in promoting wound repair and reducing inflammation in rats. Additionally, studies on female sheep have revealed similarities between their vaginal wall muscles and those of women who have given birth, making them a useful model for studying pelvic organ prolapse. The researchers are also exploring the potential of endometrial stem cells in diagnosing and treating conditions such as implantation failure, recurrent pregnancy loss, uterine scarring, and endometriosis. [Extracted from the article]

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