Findings from Columbia University Provide New Insights into Science (Mdm2 requires Sprouty4 to regulate focal adhesion formation and metastasis independent of p53).

A recent report from Columbia University highlights the multiple functions of the Mdm2 protein, which is known for its role in regulating the p53 tumor suppressor protein. The study found that Mdm2 can also regulate cell migration, invasion, cell spreading, and focal adhesion formation, independent of p53. The researchers discovered that Mdm2 downregulates the expression of Sprouty4, which is necessary for its effects on cell migration and metastasis. These findings provide new insights into the molecular mechanisms underlying metastasis and suggest that targeting Mdm2 and Sprouty4 could be a potential therapeutic strategy. [Extracted from the article]

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