A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : American Society For Microbiology
      Original Publication: [Bethesda, Md.] American Society for Microbiology.
    • Subject Terms:
      Antigens, CD/*metabolism ; Bacterial Outer Membrane Proteins/*metabolism ; Cell Adhesion Molecules/*metabolism ; Chinchilla/*microbiology ; Haemophilus influenzae/*physiology ; Nasopharynx/*microbiology; Animals ; Antigens, CD/chemistry ; Carrier State ; Cell Adhesion Molecules/chemistry ; Gene Expression Regulation ; HeLa Cells ; Humans
    • Abstract:
      In vitro studies suggest an important role for CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1) in infection by multiple gram-negative bacteria. However, in vivo evidence supporting this role is lacking, largely because the bacterial adhesins involved in this host-microbe association do not bind to murine-derived CEACAM1. One of several adhesins expressed by nontypeable Haemophilus influenzae (NTHI), the outer membrane protein P5-homologous adhesin (or P5), is essential for colonization of the chinchilla nasopharynx and infection of the middle ear. Here we reveal that NTHI P5 binds to the chinchilla homologue of CEACAM1 and that rabbit anti-human carcinoembryonic antigen blocks NTHI colonization of the chinchilla nasopharynx, providing the first demonstration of a role for CEACAM receptor binding by any bacterial pathogen in vivo.
    • References:
      Infect Immun. 1988 Feb;56(2):331-5. (PMID: 2892792)
      Exp Cell Res. 1987 Jul;171(1):1-15. (PMID: 3622626)
      Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14851-6. (PMID: 8962144)
      Mol Microbiol. 2003 Apr;48(1):117-29. (PMID: 12657049)
      Trends Endocrinol Metab. 2002 Aug;13(6):240-5. (PMID: 12128284)
      Curr Opin Cell Biol. 2006 Oct;18(5):565-71. (PMID: 16919437)
      Infect Immun. 2005 Jan;73(1):609-11. (PMID: 15618201)
      J Cell Sci. 2004 Mar 1;117(Pt 7):1091-104. (PMID: 14970258)
      Semin Cancer Biol. 1999 Apr;9(2):67-81. (PMID: 10202129)
      Infect Immun. 1994 May;62(5):2002-20. (PMID: 7909539)
      J Immunol Methods. 1997 Nov 10;209(1):1-15. (PMID: 9448029)
      Infect Immun. 1994 May;62(5):1710-8. (PMID: 8168932)
      Cell Microbiol. 2001 Jan;3(1):33-44. (PMID: 11207618)
      J Biol Chem. 2001 Jun 29;276(26):24331-40. (PMID: 11306560)
      Mol Microbiol. 1997 Dec;26(5):971-80. (PMID: 9426134)
      Infect Immun. 2000 Apr;68(4):2119-28. (PMID: 10722609)
      Mol Microbiol. 2005 Mar;55(5):1515-27. (PMID: 15720557)
      Infect Immun. 1999 Jun;67(6):2746-62. (PMID: 10338477)
      J Histochem Cytochem. 1988 Jul;36(7):729-39. (PMID: 3290331)
      Biochem J. 2001 Apr 15;355(Pt 2):417-23. (PMID: 11284729)
      Mol Microbiol. 1998 Nov;30(3):657-71. (PMID: 9822830)
      Nat Rev Immunol. 2006 Jun;6(6):433-46. (PMID: 16724098)
      Cells Tissues Organs. 2003;174(3):136-52. (PMID: 12835577)
      Cell Microbiol. 2007 Sep;9(9):2167-80. (PMID: 17506820)
      J Virol. 2006 Feb;80(4):1629-36. (PMID: 16439519)
      Mol Microbiol. 2001 Feb;39(4):850-62. (PMID: 11251807)
      Infect Immun. 1999 Jan;67(1):187-92. (PMID: 9864214)
      Infect Immun. 2000 May;68(5):2756-65. (PMID: 10768970)
      J Bacteriol. 2005 Jul;187(13):4627-36. (PMID: 15968074)
      J Infect Dis. 1993 Oct;168(4):865-72. (PMID: 8397268)
      Mol Microbiol. 2003 Aug;49(3):623-37. (PMID: 12864848)
      Mol Microbiol. 1996 Dec;22(5):941-50. (PMID: 8971715)
      Infect Immun. 2003 Aug;71(8):4691-9. (PMID: 12874350)
      J Exp Med. 2004 Jan 5;199(1):35-46. (PMID: 14707113)
      Vaccine. 2006 May 29;24(22):4804-11. (PMID: 16616975)
      Ann Otol Rhinol Laryngol. 1991 Sep;100(9 Pt 1):774-82. (PMID: 1952673)
      Infect Immun. 2005 Jan;73(1):599-608. (PMID: 15618200)
      J Histochem Cytochem. 1996 Jan;44(1):35-41. (PMID: 8543780)
      Infect Immun. 2003 Jun;71(6):3454-62. (PMID: 12761130)
      Microb Pathog. 1997 Aug;23(2):119-26. (PMID: 9245624)
      Vaccine. 2002 Oct 4;20(29-30):3590-7. (PMID: 12297406)
      EMBO J. 1997 Jun 16;16(12):3435-45. (PMID: 9218786)
      Infect Immun. 1997 Jun;65(6):2353-61. (PMID: 9169774)
      Mol Microbiol. 1996 Dec;22(5):929-39. (PMID: 8971714)
      Microb Pathog. 1996 Nov;21(5):343-56. (PMID: 8938642)
      Nat Immunol. 2002 Mar;3(3):229-36. (PMID: 11850628)
      Infect Immun. 1996 Apr;64(4):1477-9. (PMID: 8606123)
      Ann Otol Rhinol Laryngol. 1992 Jul;101(7):607-11. (PMID: 1626909)
      J Biol Chem. 2006 Dec 22;281(51):39179-93. (PMID: 17071610)
      Infect Immun. 2006 Feb;74(2):830-8. (PMID: 16428725)
      Vaccine. 1997 Jun;15(9):955-61. (PMID: 9261941)
      Scand J Infect Dis. 2003;35(9):614-8. (PMID: 14620144)
      J Exp Med. 1997 May 5;185(9):1557-64. (PMID: 9151893)
      Infect Immun. 2000 Jun;68(6):3601-7. (PMID: 10816518)
      Mol Immunol. 2007 Mar;44(9):2446-58. (PMID: 17113647)
    • Grant Information:
      R01 DC003915 United States DC NIDCD NIH HHS; R01-DC03915 United States DC NIDCD NIH HHS
    • Accession Number:
      0 (Antigens, CD)
      0 (Bacterial Outer Membrane Proteins)
      0 (CD66 antigens)
      0 (Cell Adhesion Molecules)
      149024-69-1 (OMPA outer membrane proteins)
    • Publication Date:
      Date Created: 20071017 Date Completed: 20080125 Latest Revision: 20211020
    • Publication Date:
      20231215
    • Accession Number:
      PMC2223670
    • Accession Number:
      10.1128/IAI.00980-07
    • Accession Number:
      17938212