DNA Cleavage and Trypanosomes Death by a Combination of Alamar Blue and Au(III)

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  • Author(s): By:Ahsan Habib, Tatsuru Hara, Aklima Nargis, Elvis Ny
  • Source:
    Journal of the Chemical Society of Pakistan (Karachi, Pakistan), February 29, 2020 News, 15pp
  • Additional Information
    • Abstract:
      Summary: Alamar Blue test indicates toxicity of Au(III), but Au(III) ion itself is not toxic in vitro and does not cleave DNA. However, combination of Alamar Blue and Au(III) cleaved DNA through formation of O 2-. and H 2 O 2 and showed high toxicity on Trypanosoma brucei brucei that causes African Sleeping Sickness (Trypanosomiasis) in vitro and in vivo tests...