Runx3 Acts as Homodimeric Chromatin Binding Factor Regulating Heterochromatin-Mediated Cancerous Phenotype.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Abstract:
      A preprint abstract from biorxiv.org discusses the role of the Runx3 protein in tumorigenesis, specifically in metastatic gastric cancer. The study found that Runx3 acts as a chromatin modulator and binds to modified nucleosomes as a homodimer. Depletion of Runx3 led to increased nucleosome occupancy and chromatin silencing through heterochromatin condensation and HP1 oligomerization. The study also identified dysregulation of inflammatory response and DNA repair pathways due to Runx3 null expression. These findings suggest that Runx3 plays a crucial role in maintaining the cancerous phenotype. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]
    • Abstract:
      Copyright of Cancer Weekly is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)