A new method of screening for diabetic neuropathy using laser Doppler and photoplethysmography.

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  • Author(s): Kim SW;Kim SW; Kim SC; Nam KC; Kang ES; Im JJ; Kim DW
  • Source:
    Medical & biological engineering & computing [Med Biol Eng Comput] 2008 Jan; Vol. 46 (1), pp. 61-7. Date of Electronic Publication: 2007 Oct 10.
  • Publication Type:
    Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 7704869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1741-0444 (Electronic) Linking ISSN: 01400118 NLM ISO Abbreviation: Med Biol Eng Comput Subsets: MEDLINE
    • Publication Information:
      Publication: New York, NY : Springer
      Original Publication: Stevenage, Eng., Peregrinus.
    • Subject Terms:
      Diabetic Neuropathies/*diagnosis; Aged ; Blood Volume ; Female ; Fingers/blood supply ; Humans ; Laser-Doppler Flowmetry/methods ; Male ; Mass Screening/methods ; Middle Aged ; Photoplethysmography/methods ; Sensitivity and Specificity ; Skin Temperature ; Toes/blood supply
    • Abstract:
      The purpose of this study is to suggest a simple, new method of screening for diabetic neuropathy. We measured blood volume changes by photoplethysmography (PPG) and blood perfusion by laser Doppler (LD) in the index fingers and big toes in 40 control subjects and in 50 (19 mild, 17 moderate, and 14 severe based on the nerve conduction velocity (NCV) test) and 35 diabetic patients with and without neuropathy, respectively. According to the results of PPG and LD measurements, the toe to finger ratios obtained from the neuropathic group were significantly higher than those from the control (p < 0.001) and the non-neuropathic groups (p < 0.001). Based on the NCV, the sensitivity of the LD method (92.0%) was higher than that of the PPG method (84.0%) for both left and right sides. Although specificity of the LD (92.8%) was also higher than the PPG (84.3%) bilaterally, the PPG showed better reproducibility (5.5 versus 9.5%) and a significant ratio increase with severity, while the LD did not. Our suggested PPG method using the toe to finger ratio is reliable, simple, economical, and accurate, and could become an effective new screening tool for the early detection of diabetic neuropathy.
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    • Publication Date:
      Date Created: 20071012 Date Completed: 20090616 Latest Revision: 20211020
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/s11517-007-0257-z
    • Accession Number:
      17929071