Impact of diabetes on the severity of liver disease.

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  • Author(s): Hickman IJ;Hickman IJ; Macdonald GA
  • Source:
    The American journal of medicine [Am J Med] 2007 Oct; Vol. 120 (10), pp. 829-34.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0267200 Publication Model: Print Cited Medium: Internet ISSN: 1555-7162 (Electronic) Linking ISSN: 00029343 NLM ISO Abbreviation: Am J Med Subsets: MEDLINE
    • Publication Information:
      Publication: New York, NY : Excerpta Medica
      Original Publication: New York, Donnelly.
    • Subject Terms:
      Diabetes Mellitus, Type 2/*epidemiology ; Diabetes Mellitus, Type 2/*physiopathology ; Liver Diseases/*epidemiology ; Liver Diseases/*physiopathology; Causality ; Chronic Disease ; Comorbidity ; Disease Progression ; Female ; Humans ; Insulin Resistance ; Male ; Obesity/epidemiology ; Obesity/physiopathology ; Prevalence ; Risk Factors ; Severity of Illness Index ; United States/epidemiology
    • Abstract:
      The prevalence of type 2 diabetes is higher in patients who have liver diseases, such as nonalcoholic fatty liver disease, chronic viral hepatitis, hemochromatosis, alcoholic liver disease, and cirrhosis. The development of diabetes in patients with cirrhosis is well recognized, but evidence is emerging that the development of chronic liver disease and progression to cirrhosis may occur after the diagnosis of diabetes and that diabetes plays a role in the initiation and progression of liver injury. This article provides an overview of the evidence for an increased prevalence of diabetes in a range of liver diseases; the effect of diabetes on the severity of disease; the potential mechanisms whereby coexistent diabetes exacerbates progression of hepatic fibrosis; and the impact of obesity, insulin resistance, and type 2 diabetes on clinical outcomes.
    • Number of References:
      76
    • Publication Date:
      Date Created: 20071002 Date Completed: 20071030 Latest Revision: 20220330
    • Publication Date:
      20240628
    • Accession Number:
      10.1016/j.amjmed.2007.03.025
    • Accession Number:
      17904449