University of Georgia Researchers Describe Research in Avian Influenza (Bird Flu) (Mass vaccination with reassortment-impaired live H9N2 avian influenza vaccine).

Researchers from the University of Georgia have developed a modified live virus (MLV) vaccine for avian influenza (bird flu) that is safe, immunogenic, and protective. The vaccine, called MLV-H9N2-IL, was engineered to be reassortment-impaired and non-transmissible, addressing concerns about unintended transmission. In tests on chickens, the vaccine demonstrated stability, comparable virus titers to the wild-type strain, and no transmission via direct contact. Vaccinated chickens showed no clinical signs, seroconverted, and had a significant decrease in viral loads post-challenge. This study lays the groundwork for the development of safe MLVs suitable for mass vaccination efforts against avian influenza. [Extracted from the article]

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