EVALUACIÓN TOXICOLÓGICA DE MATERIALES MEDIANTE EL ORGANISMO MODELO CAENORHABDITIS ELEGANS.

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    • Subject Terms:
      HUMAN ecology; CELL survival; INTESTINES; IMMUNE system; ANIMAL models in research
    • Abstract:
      El artículo presenta la evaluación toxicológica de materiales utilizando el organismo modelo Caenorhabditis elegans. Se destaca el desarrollo de organoides intestinales de ratón y oveja a partir de células de las criptas intestinales, lo que permite implementar un sistema de alto rendimiento para el cribado de compuestos. Además, se utiliza la técnica de azul alamar para calcular la viabilidad celular de los organoides y se emplea un modelo de barrera intestinal in vitro mediante la incorporación de células del sistema inmunológico. Este modelo de organoides intestinales tiene como objetivo reducir la dependencia de modelos animales tradicionales y mejorar la capacidad de proteger la salud humana y el medio ambiente. [Extracted from the article]
    • Abstract:
      The article presents the toxicological evaluation of materials using the model organism Caenorhabditis elegans. The development of mouse and sheep intestinal organoids from intestinal crypt cells is highlighted, allowing for the implementation of a high-throughput system for compound screening. Additionally, the alamar blue technique is used to calculate the cell viability of the organoids, and an in vitro intestinal barrier model is employed by incorporating cells from the immune system. The aim of this intestinal organoid model is to reduce reliance on traditional animal models and improve the ability to protect human health and the environment. [Extracted from the article]
    • Abstract:
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