The intersection of endocrine signaling and neuroimmune communication regulates neonatal nociception.

A recent preprint abstract discusses the mechanisms of neonatal pain and the potential role of endocrine signaling and neuroimmune communication in regulating it. The study found that local growth hormone (GH) treatment inhibited neonatal inflammatory myalgia through a unique signal transducer and activator of transcription (STAT) dependent pathway within sensory neurons. The STAT1 transcription factor appeared to regulate peripheral inflammation by modulating the release of monocyte chemoattractant protein 1 (MCP1) from sensory neurons. These findings could potentially lead to new treatments for muscle pain and inflammation in neonates. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

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