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Macrophage activation syndrome as a presenting feature in juvenile systemic lupus erythematosus.
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- Author(s): Ramadoss, Ishwarya (AUTHOR) ; Rengabashyam, Pirahalathan (AUTHOR); Seetharaman Varadhan, Mythili (AUTHOR); Ponniah Subramanian, Arul R (AUTHOR)
- Source:
Lupus. Aug2024, p1.- Subject Terms:
- Source:
- Additional Information
- Abstract: Macrophage activation syndrome (MAS) is an acquired form of hemo phagocytic lymphohistiocytosis (HLH) and is usually associated with infections, autoimmune, auto inflammatory syndromes and malignancies.A 14 year old girl presented with sub-acute onset of fever with lymphadenopathy, pancytopenia,high ferritin values and a falling erythrocyte sedimentation rate. She was evaluated with relevant laboratory tests that was suggestive of systemic Lupus erythematosus and associated macrophage activation syndrome She recovered with immunosuppressive therapy and other supportive care.There is a need for a high index of suspicion of occult MAS and MAS in patients with systemic lupus erythematosus as it may be an initial presentation. Delay in diagnosis and initiation of treatment can lead to a higher mortality. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Lupus is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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