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Treatment of Post-Tonsillectomy Hemorrhage With Nebulized Tranexamic Acid: Initial Investigation of a Novel Therapeutic Modality.
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- Author(s): Maksimoski, Matthew; McCauley, Matthew; Osoba, Muyinat; Pirotte, Matthew; Liddy, Whitney
- Source:
Annals of Otology, Rhinology & Laryngology; Aug2024, Vol. 133 Issue 8, p729-734, 6p- Subject Terms:
ACADEMIC medical centers; SURGERY; PATIENTS; TONSILLECTOMY; EMERGENCY room visits; TREATMENT effectiveness; RETROSPECTIVE studies; SURGICAL complications; LONGITUDINAL method; NEBULIZERS & vaporizers; OPIOID analgesics; MEDICAL records; ACQUISITION of data; TRANEXAMIC acid; GENERAL anesthesia; HEMORRHAGE; PATIENT aftercare - Source:
- Additional Information
- Subject Terms:
- Abstract: Objectives: The use of nebulized tranexamic acid (TXA) in massive pulmonary hemorrhage is well-described. Published utilization in post-tonsillectomy bleeding (PTB) is limited to a single case. This study examines whether TXA resulted in change of operative intervention necessity and narcotic utilization. Methods: This was a retrospective cohort study at a single, urban academic medical center in the United States. Chart review was conducted of all patients who presented to the hospital for post-tonsillectomy bleed (PTB) between 3/1/2018 and 7/1/2020. Demographic data, intervention modality, need for control under general anesthesia, and opioid use were collected and analyzed. Results: Twenty-one patients underwent a total of 23 visits for PTB over the study period. Control of hemorrhage without need for operating room intervention for PTB was 100% (6/6) for patients receiving TXA nebulizer and 53% (9/17) for those receiving other treatment modalities. Opioid usage in hospital and on discharge was also lower in patients receiving TXA nebulizers. All results were statistically significant. Conclusions: Our study supports nebulized TXA as an effective, non-invasive mode of hemostasis in patients presenting to the emergency department for post-tonsillectomy hemorrhage. Nebulized TXA may prevent the need for general anesthesia and operative intervention. Otolaryngologists should consider addition of this novel treatment appropriation of TXA to their management options for postoperative tonsillar hemorrhage. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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