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John L. Dart Library
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Phone: (843) 722-7550
West Ashley Library
9 a.m. – 7 p.m.
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Folly Beach Library
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Wando Mount Pleasant Library
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Village Library
9 a.m. – 6 p.m.
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St. Paul's/Hollywood Library
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Familial oral lichen planus: A new risk group for oral cancer?
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- Author(s): Czerninski, Rakefet; Awadieh, Zinat; Feldman, Svetlana; Keshet, Naama; Zlotogorski, Abraham; Ramot, Yuval
- Source:
Oral Diseases; Jul2024, Vol. 30 Issue 5, p3018-3027, 10p- Subject Terms:
FAMILIES & psychology; LIFESTYLES; MEDICAL history taking; RISK assessment; NEOPLASTIC cell transformation; JEWS; MOUTH tumors; HYPERLIPIDEMIA; CARDIOVASCULAR diseases; RESEARCH funding; SMOKING; THYROID diseases; DESCRIPTIVE statistics; ARABS; QUALITY of life; ORAL lichen planus; SOCIODEMOGRAPHIC factors; ALCOHOL drinking; DISEASE incidence; COMORBIDITY; DISEASE risk factors - Source:
- Additional Information
- Subject Terms:
- Abstract: Objective: The familial type of oral lichen planus (OLP) is rare, with a paucity of data regarding its clinical significance. Our objective was to characterize patients with familial OLP. Methods: Families with at least two members diagnosed with OLP were included. Clinical and demographic data and medical history were recorded. Results: Twenty families, 19 Jewish and 1 Arab, were identified. Of the Jewish families, 57.8% were non‐Ashkenazi, originating mainly from central Asia. Of those with OLP there were 14 males and 23 females with an average age of 49.1. Dyslipidemia, cardiovascular, and thyroid disorders (27.7%, 22.2%, and 16.6%, respectively) were the most common comorbidities. Five patients from five distinct families had oral cancer, two with second primary. Conclusions: To the best of our knowledge, this is the largest study describing familial OLP. The predominant and common ethnicity of the families with multiple members diagnosed with OLP may imply an ethnic tendency. The higher tendency of hypothyroidism and the high percentage of OSCC among familial OLP patients might be connected to familial OLP and the latter suggests that this population is predisposed to malignant transformation. Thus, this group should be considered as a high‐risk group. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Oral Diseases is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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