Analysis of oral lichen planus severity on micro‐RNA linked with malignant transformation risks.

Objective: The present study evaluated the oral tissue expression of micro‐RNA (miRNAs) linked to the potential malignant evolution of oral lichen planus (OLP). Furthermore, the correlation between OLP severity and miRNAs expression was assessed, and possible predictors of miRNAs in OLP patients were identified. Methods: The present study enrolled 41 patients with OLP (median age 58 years) and 42 healthy controls (median age 59 years). In each patient, miRNA levels (miR‐7a‐3p,‐7a2‐3p,‐7a‐5p,‐21‐3p,‐21‐5p,‐100‐3p,‐100‐5p,‐125b‐2‐3p,‐125b‐5p,‐200b‐3p,‐200b‐5p) were assessed and analyzed through reverse transcription polymerase chain reaction. Clinical parameters and the eventual presence of OLP symptoms, signs, and disease severity scores in each patient were reported using an anamnestic questionnaire. Results: In comparison with healthy controls, OLP patients showed significantly higher miR‐7a‐3p,‐7a‐2‐3p,‐21‐3p, miR‐21‐5p and miR‐100‐5p levels (p < 0.05) and significantly lower miR‐125b‐2‐3p,‐125b‐5p,‐200b‐3p, and ‐200b‐5p levels (p < 0.05). Furthermore, OLP symptoms and signs and disease severity scores were significantly correlated and were also predictors of all analyzed miRNAs (p < 0.05). Conclusions: In comparison with healthy subjects, OLP patients exhibited unbalanced oral miRNAs expression linked to the risk of potential malignant evolution of OLP. Furthermore, some miRNAs were correlated with OLP extent and were significant predictors of OLP symptoms, signs, and disease severity scores. [ABSTRACT FROM AUTHOR]

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