TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk.

According to a preprint abstract, Toll-like receptors (TLRs) are proteins that recognize microbial components or cellular danger signals to activate signaling pathways that induce anti-microbial and inflammatory genes. TLR9, a protein found in endosomes, requires activation by the tyrosine kinase EGFR and two Src family kinases, Syk and Lyn, to phosphorylate and activate TLR9. This phosphorylation is critical for TLR9-mediated intracellular signaling. The study also found that blocking EGFR activity or knocking out the EGFR gene suppressed TLR9-induced hepatotoxicity. However, it should be noted that this preprint has not been peer-reviewed. [Extracted from the article]

Copyright of Health & Medicine Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)