Researchers at University of Mustansiriyah Zero in on Enzymes and Coenzymes [In silico Study of New Five-Membered Heterocyclic Derivatives Bearing (1,3,4-oxadiazole and 1,3,4-thiadiazole) As Promising Cyclooxygenase Inhibitors].

Researchers at the University of Mustansiriyah in Baghdad, Iraq, have conducted a study on enzymes and coenzymes. They designed, synthesized, and evaluated a series of pyrazole, oxadiazole, and thiadiazole compounds for their anti-inflammatory activity against cyclooxygenase enzyme 2. The compounds showed significant activity and demonstrated hydrogen bonding interactions with crucial amino acids in COX-2 isozymes. The aim of the study was to develop novel nonsteroidal anti-inflammatory drugs (NSAIDs) with reduced gastro-toxicity and higher selectivity. This research provides valuable insights for the development of new anti-inflammatory compounds. [Extracted from the article]

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