Acidic pH attenuates immune killing through inactivation of perforin.

A preprint abstract from biorxiv.org discusses the inhibitory effects of acidic pH on immune therapies for solid tumors. The study found that the acidic tumor microenvironment hinders the formation of perforin pores, which are crucial for the killing of target cells by cytotoxic lymphocytes. This discovery highlights a new obstacle in the development of effective immunotherapies for solid tumors and emphasizes the need to consider the acidic pH in treatment strategies. It is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

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