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Folly Beach Library
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Wando Mount Pleasant Library
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Beyond CAR T cells: exploring alternative cell sources for CAR-like cellular therapies.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Tsiverioti, Christina Angeliki; Gottschlich, Adrian; Trefny, Marcel; Theurich, Sebastian; Anders, Hans-Joachim; Kroiss, Matthias; Kobold, Sebastian
- Source:
Biological Chemistry; Jul2024, Vol. 405 Issue 7/8, p485-515, 31p- Subject Terms:
- Source:
- Additional Information
- Abstract: Chimeric antigen receptor (CAR)-T cell therapy has led to remarkable clinical outcomes in the treatment of hematological malignancies. However, challenges remain, such as limited infiltration into solid tumors, inadequate persistence, systemic toxicities, and manufacturing insufficiencies. The use of alternative cell sources for CAR-based therapies, such as natural killer cells (NK), macrophages (MΦ), invariant Natural Killer T (iNKT) cells, γδT cells, neutrophils, and induced pluripotent stem cells (iPSC), has emerged as a promising avenue. By harnessing these cells' inherent cytotoxic mechanisms and incorporating CAR technology, common CAR-T cell-related limitations can be effectively mitigated. We herein present an overview of the tumoricidal mechanisms, CAR designs, and manufacturing processes of CAR-NK cells, CAR-MΦ, CAR-iNKT cells, CAR-γδT cells, CAR-neutrophils, and iPSC-derived CAR-cells, outlining the advantages, limitations, and potential solutions of these therapeutic strategies. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Biological Chemistry is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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