Postprandiálna hypotenzia -- možný kardiovaskulárny rizikový faktor? (Slovak)

Postprandial hypotension -- a possible cardiovascular risk factor? (English)

Postprandial hypotension (PPH) is an excessive drop in blood pressure after eating, which can lead to clinical symptoms such as weakness, dizziness, falls, transient ischemic attacks of the central nervous system, angina pectoris or syncope. PPH is defined as a drop in systolic blood pressure (SBP) of 20 mmHg or more within two hours after a meal. PPH is more often observed in older patients, especially with an associated autonomic disorder (patients with diabetes mellitus, renal insufficiency, Parkinson's disease) but also long-lasting hypertension. Pathogenetic mechanisms of PPH include increased splanchnic pooling, impaired sympathetic nervous system, decreased postprandial baroreflex activity, and neurohumoral mechanisms. Attention is currently being paid mainly to the role of intestinal peptides in the development of PPH. Influencing the secretion of intestinal peptides is one of the promising methods for the treatment of postprandial hypotension. [ABSTRACT FROM AUTHOR]

Postprandiálna hypotenzia (PPH) je nadmerný pokles tlaku krvi po príjme potravy, ktorý môže viesť k vzniku klinických symptómov, ako sú slabosť, závraty, pády, prechodné ischemické ataky centrálneho nervového systému, angína pektoris alebo synkopa. PPH je definovaná ako zníženie systolického krvného tlaku (STK) o 20 mmHg alebo viac v priebehu dvoch hodín po jedle. PPH sa častejšie pozoruje u pacientov vyššieho veku najmä s pridruženou autonómnou poruchou (pacienti s diabetes mellitus, renálnou insuficienciou, Parkinsonovou chorobou), ale aj dlhotrvajúcou hypertenziou. Patogenetické mechanizmy PPH zahŕňajú zvýšený splanchnický pooling, poruchu sympatikového nervového systému, zníženú aktivitu baroreflexu po príjme potravy a neurohumorálne mechanizmy. Pozornosť sa v súčasnosti venuje najmä úlohe črevných peptidov pri vzniku PPH. Ovplyvnenie sekrécie črevných peptidov patrí k perspektívnym metódam liečby postprandiálnej hypotenzie. [ABSTRACT FROM AUTHOR]

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