Unmasking immune suppression.

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    • Subject Terms:
      IMMUNOSUPPRESSION; T cells; REGULATORY T cells; SUPPRESSOR cells; MYELOID-derived suppressor cells; CYTOTOXIC T cells
    • Abstract:
      The article discusses a study led by Jason R. Pitarresi and Katherine A. Fitzgerald, focusing on the immune-suppressive effects of mutated isocitrate dehydrogenase 1 (IDH1) in cancer. It highlights how mutant IDH1 generates the oncometabolite (R)-2-hydroxyglutarate (R-2HG), which alters the epigenetic state of tumor cells. It demonstrates that inhibiting mutant IDH1 can reverse these effects, potentially enhancing antitumor immunity in cancers such as intrahepatic cholangiocarcinoma and glioma.