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Phone: (843) 722-7550
West Ashley Library
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Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Quality of life gains in frail and intermediate-fit patients with multiple Myeloma: Findings from the prospective HOVON123 clinical trial.
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- Author(s): Seefat, M.R.1 (AUTHOR); Stege, C.A.M.1,2 (AUTHOR); Lissenberg-Witte, B.I.3 (AUTHOR); Levin, M.D.4 (AUTHOR); Timmers, G.J.5 (AUTHOR); Hoogendoorn, M.6 (AUTHOR); Ypma, P.F.7 (AUTHOR); Klein, S.K.8,9 (AUTHOR); Velders, G.A.10 (AUTHOR); Westerman, M.11 (AUTHOR); Strobbe, L.12 (AUTHOR); Durdu-Rayman, N.13 (AUTHOR); Davidis-van Schoonhoven, M.A.14 (AUTHOR); van Kampen, R.J.W.15 (AUTHOR); Dijk, A.C.16 (AUTHOR); Koster, A.17 (AUTHOR); Silbermann, M.H.18 (AUTHOR); van der Spek, E.19 (AUTHOR); Beeker, A.20 (AUTHOR); Erjavec, Z.21 (AUTHOR)
- Source:
European Journal of Cancer. Aug2024, Vol. 207, pN.PAG-N.PAG. 1p.- Subject Terms:
*THERAPEUTIC use of antineoplastic agents; *MULTIPLE myeloma; *PATIENT compliance; *FRAIL elderly; *ANTINEOPLASTIC agents; *CLINICAL trials; *FATIGUE (Physiology); *QUESTIONNAIRES; *PREDNISONE; *DESCRIPTIVE statistics; *BORTEZOMIB; *MELPHALAN; *LONGITUDINAL method; *QUALITY of life; *PAIN; *COMPARATIVE studies - Source:
- Additional Information
- Abstract: Frailty in newly-diagnosed multiple myeloma (NDMM) patients is associated with treatment-related toxicity, which negatively affects health-related quality of life (HRQoL). Currently, data on changes in HRQoL of frail and intermediate-fit MM patients during active treatment and post-treatment follow-up are absent. The HOVON123 study (NTR4244) was a phase II trial in which NDMM patients ≥ 75 years were treated with nine dose-adjusted cycles of Melphalan-Prednisone-Bortezomib (MPV). Two HRQoL instruments (EORTC QLQ-C30 and -MY20) were obtained before start of treatment, after 3 and 9 months of treatment and 6 and 12 months after treatment for patients who did not yet start second-line treatment. HRQoL changes and/or differences in frail and intermediate-fit patients (IMWG frailty score) were reported only when both statistically significant (p < 0.005) and clinically relevant (>MID). 137 frail and 71 intermediate-fit patients were included in the analysis. Compliance was high and comparable in both groups. At baseline, frail patients reported lower global health status, lower physical functioning scores and more fatigue and pain compared to intermediate-fit patients. Both groups improved in global health status and future perspective; polyneuropathy complaints worsened over time. Frail patients improved over time in physical functioning, fatigue and pain. Improvement in global health status occurred earlier than in intermediate-fit patients. HRQoL improved during anti-myeloma treatment in both intermediate-fit and frail MM patients. In frail patients, improvement occurred faster and, in more domains, which was retained during follow-up. This implies that physicians should not withhold safe and effective therapies from frail patients in fear of HRQoL deterioration. • HRQoL differs between intermediate-fit & frail patients before start of MM therapy. • HRQoL improves in both intermediate-fit & frail patients during initial MM therapy. • Frail patients show faster & larger improvements in HRQoL during first treatment. • Improvements in HRQoL persist during post-treatment follow-up. • Physicians should not refrain from treating frail patients in fear of HRQoL loss. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Journal of Cancer is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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