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Folly Beach Library
9 a.m. - 2 p.m.
*open the 2nd and 4th Saturday
*open the 2nd and 4th Saturday
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. - 5 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. - 5 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
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Phone: (843) 889-3300
Otranto Road Library
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Phone: (843) 572-4094
Mt. Pleasant Library
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
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Dorchester Road Library
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Phone: (843) 805-6909
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Moderate‐to‐severe cognitive impairment is associated with both recent and chronic alcohol misuse in people with HIV: The New Orleans alcohol use in HIV (NOAH) study.
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- Author(s): Fitzpatrick‐Schmidt, Taylor; Oral, Evrim; Welsh, David A.; Molina, Patricia E.; Ferguson, Tekeda F.; Edwards, Scott
- Source:
Alcohol: Clinical & Experimental Research; Jul2024, Vol. 48 Issue 7, p1405-1416, 12p- Subject Terms:
HIV infection complications; ALCOHOLISM risk factors; RISK assessment; CROSS-sectional method; LANGUAGE & languages; PEARSON correlation (Statistics); MILD cognitive impairment; RESEARCH funding; PHOSPHOLIPIDS; T-test (Statistics); MENTAL illness; ETHANOL; AT-risk people; DISEASE prevalence; DESCRIPTIVE statistics; CHI-squared test; ALCOHOL-induced disorders; DRUG use testing; LONGITUDINAL method; COGNITION disorders; NEUROPSYCHOLOGICAL tests; MEMORY; ALCOHOLISM; ALCOHOL drinking; COMPARATIVE studies; DATA analysis software; COGNITION; COMORBIDITY; ACTIVE aging - Source:
- Additional Information
- Subject Terms:
- Abstract: Background: Human immunodeficiency virus (HIV) profoundly impacts the nervous system, leading to neurological deficits including HIV‐associated neurocognitive disorder (HAND). HAND represents the most common neurological comorbidity among people with HIV (PWH), and alcohol use may exacerbate cognitive deficits, especially in vulnerable populations. This study investigated relationships between alcohol use and cognition in an underserved cohort of PWH, on the hypothesis that alcohol misuse exacerbates cognitive deficits. Methods: Data collected from participants (n = 259; 66.7% male; mean age 52 ± 10 years) enrolled in the New Orleans Alcohol Use in HIV (NOAH) study were utilized for cross‐sectional analysis. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), and alcohol use was comprehensively measured using four metrics: the Alcohol Use Disorders Identification Test (AUDIT), 30‐day timeline follow back (TLFB), lifetime drinking history, and phosphatidylethanol (PEth) levels. Results: The average MoCA score among participants was 20.7 ± 4.5, with 86.5% demonstrating cognitive impairment (MoCA < 26). Individuals with MoCA scores below 18 (moderately or severely cognitively impaired) had a higher frequency of recent severe alcohol misuse and greater lifetime alcohol consumption. Participants at increased risk for AUD (AUDIT ≥ 16) also had worse global cognition and memory task performance than those with lower AUDIT scores; this was particularly true among those aged 50 and older. Analysis of the MoCA sub‐score data indicated that participants with increased AUD risk had impairments in the cognitive domains of language and memory. Conclusions: Our findings demonstrate a high prevalence of cognitive impairment in the NOAH cohort and suggest that alcohol misuse contributes to global cognitive deficits in PWH, especially among individuals aged 50 and older. Further exploration of the impact of alcohol use on specific cognitive domains, including memory and language, should incorporate additional cognitive tasks. These findings highlight the importance of considering alcohol use and AUD risk as significant factors that may exacerbate cognitive deficits in vulnerable populations, including older PWH. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Alcohol: Clinical & Experimental Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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