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Folly Beach Library
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Wando Mount Pleasant Library
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Application of 3D bioprinting technology apply to assessing Dangguiniantongtang (DGNT) decoctions in arthritis.
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- Author(s): Liang, Zhichao; Han, Yunxi; Chen, Tao; Wang, Jinwu; Lin, Kaili; Yuan, Luying; Li, Xuefei; Xu, Hao; Wang, Tengteng; Liu, Yang; Xiao, Lianbo; Liang, Qianqian
- Source:
Chinese Medicine; 7/8/2024, Vol. 19 Issue 1, p1-12, 12p- Subject Terms:
DRUG therapy for arthritis; CHINESE medicine; BIOLOGICAL models; OSTEOBLASTS; RESEARCH funding; HERBAL medicine; POLYMERASE chain reaction; TRANSCRIPTION factors; ALKALINE phosphatase; PLANT extracts; CELL lines; BIOMEDICAL materials; GENE expression; BONE morphogenetic proteins; EXPERIMENTAL design; CARTILAGE cells; LIPOPOLYSACCHARIDES; DRUG efficacy; THREE-dimensional printing; COLLAGEN; INTERLEUKINS - Source:
- Additional Information
- Abstract: The aim of this study was to develop a three-dimensional (3D) cell model in order to evaluate the effectiveness of a traditional Chinese medicine decoction in the treatment of arthritis. Chondrocytes (ATDC5) and osteoblasts (MC3T3-E1) were 3D printed separately using methacryloyl gelatin (GelMA) hydrogel bioinks to mimic the natural 3D cell environment. Both cell types showed good biocompatibility in GelMA. Lipopolysaccharide (LPS) was added to the cell models to create inflammation models, which resulted in increased expression of inflammatory factors IL-1β, TNF-α, iNOS, and IL-6, and decreased expression of cell functional genes such as Collagen II (COLII), transcription factor SOX-9 (Sox9), Aggrecan, alkaline phosphatase (ALP), RUNX family transcription factor 2 (Runx2), Collagen I (COLI), Osteopontin (OPN), and bone morphogenetic protein-2 (BMP-2). The created inflammation model was then used to evaluate the effectiveness of Dangguiniantongtang (DGNT) decoctions. The results showed that DGNT reduced the expression of inflammatory factors and increased the expression of functional genes in the cell model. In summary, this study established a 3D cell model to assess the effectiveness of traditional Chinese medicine (TCM) decoctions, characterized the gene expression profile of the inflammatory state model, and provided a practical reference for future research on TCM efficacy evaluation for arthritis treatment. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Chinese Medicine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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