Apolipoprotein E in dense deposits: a parting of the ways in C3 glomerulopathy.

A recent study conducted at the Mayo Clinic by Benjamin Madden and Sanjeev Sethi has shed light on the pathophysiology of dense deposit disease (DDD), a subtype of C3 glomerulopathy (C3G). The researchers used laser capture microdissection and mass spectrometry to analyze the major components of deposits in DDD and compared them to C3 glomerulonephritis (C3GN) and control cases. They found that DDD was enriched with apolipoprotein E (apoE) compared to C3GN and control cases, suggesting that apoE staining could be a useful alternative to electron microscopy for diagnosing DDD. However, further research is needed to understand the biological implications of apoE in DDD. [Extracted from the article]

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