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Folly Beach Library
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Wando Mount Pleasant Library
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Village Library
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Phone: (843) 884-9741
St. Paul's/Hollywood Library
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McClellanville Library
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AEBP1 upregulation contributes to cervical cancer progression by facilitating cell proliferation, migration, and invasion.
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- Author(s): Liu, Songjun; Gu, Yanpin; Shi, Yin; Yu, Shuqian; Li, Wu; Lv, Wen
- Source:
Journal of Obstetrics & Gynaecology Research; Jul2024, Vol. 50 Issue 7, p1166-1174, 9p- Subject Terms:
PROTEINS; CERVIX uteri tumors; CANCER invasiveness; PHOSPHORYLATION; SKELETAL muscle; MACROPHAGES; T-test (Statistics); STATISTICAL significance; RESEARCH funding; CELL proliferation; CELL physiology; NEUTROPHILS; CELL motility; CELLULAR signal transduction; REVERSE transcriptase polymerase chain reaction; DESCRIPTIVE statistics; IMMUNOHISTOCHEMISTRY; CELL lines; BIOINFORMATICS; GENE expression profiling; WESTERN immunoblotting; STAT proteins; INFLAMMATION; DATA analysis software; DISEASE progression; GRANULOCYTES - Source:
- Additional Information
- Abstract: Background: Aberrant expression of adipocyte enhancer‐binding protein 1 (AEBP1) has been demonstrated to be involved in the tumorigenesis and progression of numerous cancers. This study was aimed to investigate the mechanism of AEBP1 in the development of cervical cancer. Methods: The expression of AEBP1 in cervical cancer was assessed by immunohistochemistry. The function of AEBP1 on cell proliferation, migration, and invasion was determined by methyl thiazolyl tetrazolium assay, colony formation, and transwell assay. The activation of related signaling pathway was determined by western blot. The bioinformatics analysis was performed by Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Results: Higher protein expression of AEBP1 was observed in patients with cervical cancer. Overexpressed AEBP1 promoted cell proliferation, migration, and invasion abilities in cervical cancer cells. Moreover, the research manifested that AEBP1 activated the phosphorylation of STAT3. GO and KEGG analysis showed that genes positively related to AEBP1 were highly enriched in functions like epithelial cell proliferation, muscle cell migration, myoblast migration, smooth muscle tissue development, ECM–receptor interaction, transcriptional misregulation in cancer, and proteoglycans in cancer. While genes negatively related to AEBP1 were associated with immunity, including inflammatory response, external‐stimulus response, neutrophil, granulocyte, and macrophage chemotaxis. Conclusions: This study suggested that AEBP1 acts as an oncogened and might be a potential therapeutic target for the treatment of cervical cancer. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Obstetrics & Gynaecology Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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