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![loading](/sites/all/modules/hf_eds/images/loading.gif)
Ginsenoside Rk1 Ameliorates ER Stress-Induced Apoptosis through Directly Activating IGF-1R in Mouse Pancreatic β-Cells and Diabetic Pancreas.
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- Author(s): Vong, Chi Teng (AUTHOR); Tan, Dechao (AUTHOR); Liao, Fengyun (AUTHOR); Chen, Zhejie (AUTHOR); Chen, Zhangmei (AUTHOR); Tseng, Hisa Hui Ling (AUTHOR); Cheang, Wai San (AUTHOR); Wang, Shengpeng (AUTHOR); Wang, Yitao (AUTHOR)
- Source:
American Journal of Chinese Medicine. 2024, Vol. 52 Issue 4, p1195-1211. 17p. - Source:
- Additional Information
- Subject Terms: COMPUTER-assisted molecular modeling; PROTEIN kinases; PHOSPHOLIPIDS; RESEARCH funding; ENDOPLASMIC reticulum; APOPTOSIS; PANCREATIC beta cells; ENZYME-linked immunosorbent assay; OXIDATIVE stress; DESCRIPTIVE statistics; CELLULAR signal transduction; PANCREAS; CELL lines; MICE; GENE expression; GLYCOSIDES; TYPE 2 diabetes; ANIMAL experimentation; WESTERN immunoblotting; ONE-way analysis of variance; MOLECULAR structure; CELL receptors; CONNECTIVE tissue growth factor; CASPASES; IMMUNOBLOTTING
- Abstract: Hyperglycemia induces chronic stresses, such as oxidative stress and endoplasmic reticulum (ER) stress, which can result in β -cell dysfunction and development of Type 2 Diabetes Mellitus (T2DM). Ginsenoside Rk1 is a minor ginsenoside isolated from Ginseng. It has been shown to exert anti-cancer, anti-inflammatory, anti-oxidant, and neuroprotective effects; however, its effects on pancreatic cells in T2DM have never been studied. This study aims to examine the novel effects of Ginsenoside Rk1 on ER stress-induced apoptosis in a pancreatic β -cell line MIN6 and HFD-induced diabetic pancreas, and their underlying mechanisms. We demonstrated that Ginsenoside Rk1 alleviated ER stress-induced apoptosis in MIN6 cells, which was accomplished by directly targeting and activating insulin-like growth factor 1 receptor (IGF-1R), thus activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/Bcl-2-associated agonist of cell death (Bad)-B-cell lymphoma-2 (Bcl-2) pathway. This pathway was also confirmed in an HFD-induced diabetic pancreas. Meanwhile, the use of the IGF-1R inhibitor PQ401 abolished this anti-apoptotic effect, confirming the role of IGF-1R in mediating anti-apoptosis effects exerted by Ginsenoside Rk1. Besides, Ginsenoside Rk1 reduced pancreas weights and increased pancreatic insulin contents, suggesting that it could protect the pancreas from HFD-induced diabetes. Taken together, our study provided novel protective effects of Ginsenoside Rk1 on ER stress-induced β -cell apoptosis and HFD-induced diabetic pancreases, as well as its direct target with IGF-1R, indicating that Ginsenoside Rk1 could be a potential drug for the treatment of T2DM. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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