Correlation Between Serum microRNA-18a Level and Endothelial Function and Prognosis in Female Coronary Heart Disease Patients.

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    • Abstract:
      Background: The aim was to analyze the correlation between serum microRNA (miR)- 18a level, endothelial function, and prognosis in female coronary heart disease (CHD) patients. Methods: One hundred sixtyfemale patients admitted to our hospital for the first occurrences of chest pain and tightness were divided into CHD and non-CHD groups based on the coronary angiography results. Clinical data, laboratory indexes, serum miR-18a level, and endothelial function [flow-mediated dilation (FMD) function, endothelin 1 (ET-1), and nitric oxide (NO)] were compared. Results: There were no significant differences in clinical data (except CHD family history) between 2 groups. Coronary heart disease group had significantly lower levels of NO and FMD, while significantly higher levels of miR-18a and ET-1 than non-CHD group (P < .05). Pearson correlation showed that serum miR-18a level was positively correlated with ET-1 (r = 0.492, P < .001), and negatively correlated with NO and FMD (r = -0.504, -0.307, P < .001). The receiver operating characteristic) curve showed that the area under the curve of serum miR-18a level in predicting the occurrence of CHD in women was 0.878 (95% CI: 0.828-0.928). Compared with good prognosis group, poor prognosis group had significantly lower NO, and FMD levels, while higher proportions of acute coronary syndrome, multi-vessel disease, miR-18a, and ET-1 levels (P < .05). Conclusion: The expression of serum miR-18a in female CHD patients was high, which was related to endothelial function. The increase in serum miR-18a level was a risk factor for the occurrence of MACE in female CHD patients during follow-up, and the serum miR-18a level could effectively predict the occurrence of CHD in female patients. [ABSTRACT FROM AUTHOR]
    • Abstract:
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