Data from University of Pittsburgh School of Medicine Broaden Understanding of Enzymes and Coenzymes (FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation).

A recent study conducted by the University of Pittsburgh School of Medicine has shed light on the role of enzymes and coenzymes in colorectal cancer. The study focused on the BRAFV600E mutation, which is a driver mutation in the development of colorectal cancers. The researchers found that reducing the expression of FAK (Focal adhesion kinase) increased the oncogenic activity of BRAFV600E and promoted the formation of cecal tumors. This was achieved by reducing the phosphorylation of ERK, a key signaling pathway involved in tumorigenesis. The findings suggest that a "just-right" level of ERK signaling is optimal for tumor formation, and FAK loss can help achieve this balance. [Extracted from the article]

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