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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
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McClellanville Library
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Dorchester Road Library
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Phone: (843) 805-6930
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The Psychoneurologic Symptom Cluster and Its Association With Breast Cancer Genomic Instability.
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- Author(s): Grayson, Susan C.; Sereika, Susan M.; Conley, Yvette P.; Lee, Adrian V.; Oesterreich, Steffi; Koleck, Theresa A.; Rosenzweig, Margaret Q.; Liu, Tiantong; Wesmiller, Susan W.
- Source:
Oncology Nursing Forum. Jul2024, Vol. 51 Issue 4, p391-403. 13p. - Source:
- Additional Information
- Subject Terms: BLOOD testing; BREAST tumor diagnosis; CROSS-sectional method; CLUSTER analysis (Statistics); GENOMICS; RESEARCH funding; BREAST tumors; SCIENTIFIC observation; SYMPTOMS; DNA; DESCRIPTIVE statistics; MULTIVARIATE analysis; TUMOR markers; ANXIETY; METASTASIS; ONCOGENES; DATA analysis software; FACTOR analysis; AFFECT (Psychology); HEALTH outcome assessment; PHENOTYPES; SEQUENCE analysis; GENOMES; MENTAL depression
- Subject Terms:
- Abstract: OBJECTIVES: To phenotype the psychoneurologic (PN) symptom cluster in individuals with metastatic breast cancer and associate those phenotypes with individual characteristics and cancer genomic variables from circulating tumor DNA. SAMPLE & SETTING: This study included 201 individuals with metastatic breast cancer recruited in western Pennsylvania. METHODS & VARIABLES: A descriptive, crosssectional design was used. Symptom data were collected via the MD Anderson Symptom Inventory, and cancer genomic data were collected via ultralow-pass whole-genome sequencing of circulating tumor DNA from participant blood. RESULTS: Three distinct PN symptom phenotypes were described in a population with metastatic breast cancer: mild symptoms, moderate symptoms, and severe mood-related symptoms. Breast cancer TP53 deletion was significantly associated with membership in a moderate to severe symptoms phenotype (p = 0.013). IMPLICATIONS FOR NURSING: Specific cancer genomic changes associated with increased genomic instability may be predictive of PN symptoms. This finding may enable proactive treatment or reveal new therapeutic targets for symptom management. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Oncology Nursing Forum is the property of Oncology Nursing Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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