Intermolecular interaction of chloroquine with peptide-bonded-(N)-ethyl selenol-(C)-ethanethiol.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Abstract:
      The interaction of chloroquine (CQ) with peptide-bonded-ethyl selenol and ethanethiol was experimentally and thermodynamically studied, indicating that CQ can bind to peptide-bonded active selenols through electrostatic interactions with a protonated triethylamine moiety, revealing a reasonable mechanism by which CQ inhibits thioredoxin reductase (TrxR) and significantly reduces oxidoreductase activity. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of New Journal of Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)