DNA‐Origami in der Biomedizin ‐ Trendbericht Biochemie 2024 (3/3). (German)

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    • Abstract:
      DNA origami is used in biomedicine to develop and produce new therapeutics. It enables the investigation of protein-ligand interactions, particularly in relation to cancer, and provides insights into the activation of immune cells. The arrangement of ligands on DNA origami structures influences signal activation in cancer cells and receptor activation, as well as receptor clustering in immune cells. DNA origami can be used for the development of new therapeutics and the study of immunological processes. It can also be used as a therapeutic to deliver functional macromolecules or deactivate specific proteins. The author, Amelie Heuer-Jungemann, conducts research in the field of DNA origami and its application in biomedicine. [Extracted from the article]
    • Abstract:
      Chemische Proteinsynthese: Neue Techniken in der Durchflusschemie und selektive Ligationsmethoden ermöglichen, komplexe und präzise modifizierte Peptide und Proteine für biologische Anwendungen herzustellen. Funktionelle Charakterisierung: Mit Methoden aus Mikrobiologie, chemischer Biologie und Biochemie untersuchen Forschende die molekulare Funktion bakterieller Enzyme des Mikrobioms und decken so deren Relevanz bei der Entwicklung von Darmerkrankungen auf. DNA‐Origami: Biomoleküle auf mikro‐ und nanoskopischer Ebene zu untersuchen soll helfen, neue Therapeutika zu entwickeln, herzustellen und an ihren Zielort zu bringen. Besonders die Interaktionen von Proteinen miteinander und mit Ligandenmolekülen sind dabei wichtig. [ABSTRACT FROM AUTHOR]
    • Abstract:
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