The impact of early rehabilitation in intensive care unit for COVID-19 patients.

OXYGEN saturation; EARLY medical intervention; DATA analysis; RESEARCH funding; CLINICAL trials; OXYGEN therapy; MULTIPLE regression analysis; TREATMENT effectiveness; FUNCTIONAL status; DESCRIPTIVE statistics; LONGITUDINAL method; KAPLAN-Meier estimator; INTENSIVE care units; RESEARCH methodology; STATISTICS; SURVIVAL analysis (Biometry); DATA analysis software; CONFIDENCE intervals; COVID-19; EVALUATION

To evaluate the impact of early rehabilitation in intensive care unit (ICU) on the survival and functional outcomes of COVID-19 patients admitted to ICU at acute phase. We conducted a prospective quasi-experimental study including 346 eligible COVID-19 patients from all admitted cases in an ICU in Vietnam, divided into three groups: no rehabilitation (n = 32), late rehabilitation (n = 109), and early rehabilitation (n = 205). Baseline characteristics and survival information of patient were collected with BORG-CR10 scale and PFIT; the data were collected at different time points: before intervention, when switching to oxygen-therapy, and at discharge. The control group (patients not using rehabilitation therapy) has worse survival than both early rehabilitation group (hazard ratio [HR] 0.553; 95% confidence interval [CI] 0.380–0.806; p value < 0.001) and late rehabilitation group (HR 0.374; CI 0.235–0.594; p value < 0.001). Regarding functional improvement, during the first five days, rehabilitation did not make a significant impact on the patients (p value > 0.05), however if continued from day 5 to day 20, the early-rehabilitation patients obtained a statistically significant improvement for BORG-CR10 (p value < 0.01). No clear association was found for PFIT (p value > 0.05). The research emphasises the benefits of the early rehabilitation in ICU for COVID-19 patients. Rehabilitation for severe COVID-19 patients in the intensive care unit (ICU) can improve patient survival during the ICU stay. This study suggests the benefit of early rehabilitation in ICU for COVID-19 patients. Early rehabilitation shows statistically significant improvement for exertion in patients who underwent rehabilitation at least 5 d. [ABSTRACT FROM AUTHOR]

Copyright of Disability & Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)