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Tendon extracellular-matrix-derived tissue engineering micro-tissue for Achilles tendon injury regeneration in rats.
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- Author(s): Zhang, Kaihong; Zhang, Peng; Shi, Ge; Wang, Lei; Sun, Chen; Xiang, Wei
- Source:
Journal of Orthopaedic Surgery & Research; 6/27/2024, Vol. 19 Issue 1, p1-13, 13p- Subject Terms:
ACHILLES tendon injuries; BIOMECHANICS; VASCULAR endothelial growth factors; MOTOR ability; CRYOPRESERVATION of organs, tissues, etc.; TISSUE engineering; ACHILLES tendon; DIAGNOSIS; GAIT in humans; ULTRASONIC imaging; REGENERATION (Biology); TENDON injuries; RATS; BIOMEDICAL materials; ANIMAL experimentation; CONVALESCENCE; EXTRACELLULAR matrix; COLLAGEN; HISTOLOGY - Source:
- Additional Information
- Abstract: Background: Achilles tendon is vital in maintaining the stability and function of ankle joint. It is quite difficult to achieve the structural and functional repair of Achilles tendon in tissue engineering. Methods: A tissue-engineered tendon micro-tissue was prepared using rat tail tendon extracellular matrix (TECM) combined with rat adipose stem cells (ADSCs) to repair Achilles tendon injuries. The TECM was prepared by repeated freezing and thawing. The in vitro characteristics of TECM and its effect on ADSCs proliferation were detected. This tissue-engineered tendon micro-tissue for Achilles tendon repair in vivo was evaluated based on general characteristics, gait analysis, ultrasound findings, histological analysis, and biomechanical testing. Results: The results showed that the TECM scaffold had good biocompatibility for ADSCs. At 2 weeks post-surgery, collagen types I and III and tenomodulin expression were higher, and vascular endothelial growth factor expression was lower in the micro-tissue group than other groups. At 4 and 8 weeks post-surgery, the results of histological analysis and ultrasound findings showed that the repaired tendon tissue was smooth and lustrous, and was arranged regularly and evenly in the micro-tissue group. Gait analysis confirmed that better motor function recovery was noted in micro-tissue group than other groups. In addition, the mechanical properties of the repaired tendon tissue in micro-tissue group were better than other groups. Conclusion: Tissue-engineered tendon micro-tissue fabricated by TECM and ADSCs has good biocompatibility and can promote structural and functional repair of tendon in vivo. This composite biomaterial has broad application prospects in tissue engineering. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Orthopaedic Surgery & Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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