Neuronal senescence may drive brain aging.

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    • Subject Terms:
      CELLULAR aging; AGING; DNA repair
    • Abstract:
      The article focuses on neuronal senescence, a cellular response triggered by aging-related stresses like DNA damage and oxidative stress, leading to functional decline despite neurons being postmitotic. It mentions this phenomenon challenges previous views that senescence is solely linked to proliferative exhaustion, highlighting its role in neurodegenerative diseases such as Alzheimer's and Parkinson's.